Chairpersons: Daniela Cirillo, San Raffaele Scientific Institute, and Bill Rodriguez, FIND
Welcome and introduction
Daniela Cirillo
Part I - Use of next generation sequencing for detection of anti-microbial resistance
Scaling up sequencing in order to determine sequence diversity worldwide and for the identification of genetic variants that confer resistance to all old and new anti-mycobacterial drugs
Derrick Crook, University of Oxford
The ReSeqTB initiative and recent progress in the development of the data sharing platform
Angela Starks, CDC
User-friendly platforms for large data analysis
Stefan Niemann, Borstel Research Center
Related Papers
- Hugh Salamon et al., Integration of Published Information Into a Resistance-Associated Mutation Database for Mycobacterium tuberculosis, IJID, 2015 (PDF)
- Angela M. Starks et al., Collaborative Effort for a Centralized Worldwide Tuberculosis Relational Sequencing Data Platform, CID, 2015 (PDF)
- ReSeqTB overview (PDF)
- Timothy M Walker et al., Whole-genome sequencing for prediction of Mycobacterium tuberculosis drug susceptibility and resistance: a retrospective cohort study, Lancet Infect Dis, 2015
Part II - New TB drug regimens and new priorities for DST
DST for Delamanid and quality control
Daniela Cirillo
Laboratory-based DST for Bedaquiline and introduction in countries
Leen Rigouts, Antwerp Institute of Tropical Medicine
Genetic diversity within MTB for the development of new DST
Claudio Köser, University of Cambridge
Related Papers
- Claudio Köser et al., Drug-resistance mechanisms and tuberculosis drugs, The Lancet, 2015 (PDF)
- Keller et al., Determination of MIC Distribution and Epidemiological Cut-Off Values for Bedaquiline 6 and Delamanid in Mycobacterium tuberculosis Using MGIT 960, Antimicrob. Agents Chemother., 2015 (PDF)
Part III - Biomarker research and development of tests for progression of latent TB to active disease
Diagnostic markers for accurate prediction of activation of latent tuberculosis: Progress and needs
Mark Hatherill, University of Cape Town
Target Product Profile for a test for progression of latent tuberculosis infection
Claudia Denkinger, FIND
New predictive tests for the diagnosis of tuberculosis infection: How should they be evaluated and what evidence is needed for WHO endorsement
Frank Cobelens, KNCV and AIGHD