2nd Expert Workshop on the development of tests for progression of latent tuberculosis infection (LTBI) to active disease

On 1st July 2016, the NDWG convened an expert workshop on LTBI hosted by San Raffaele Scientific Institute in Milan, Italy. The objectives of the meeting were as follows:

  • To propose a standard terminology for LTBI and LTBI diagnostics.
  • To finalize the TPP for a test of progression and define a dissemination strategy for the document
  • To prepare an advanced draft of a guidance document for the evaluate of such a test and eventually submit it for WHO approval.
  • To provide an overview of the most promising research in this area.

Meeting Report

Executive Summary


List of Participants


Introduction and objectives of the meeting - Alberto Matteelli

LTBI conception: Definitions and relevance for diagnostic products - Frank Cobelens

Preliminary results of the online consultation on the draft TPP - Susanna Capone

TTP for a test of progression: Key areas to be addressed based on survey results - Samuel Schumacher

Framework for the evaluation of new LTBI tests - Sandra Kik

Genomic signatures - Thomas Scriba

Role of CD8 in progression from latent to active TB - David Lewinsohn